Multi-Edit Lite installs and uses the Borland Delphi 6 runtime libraries and increments their Shared DLL Counter. When the uninstaller is run, the Shared DLL Counter is decremented by one and if the result is 0 then the DLL is deleted as the installer had installed it and no other program would be using it. If the result is not 0 then the DLL is not removed.
The runtime libraries for D2005 are different than the ones for Delphi 6 so you should not have an issue. Also Multi-Edit 2006 will install the Delphi 6 runtime libraries as it uses them as well.