Not sure what you mean by "line number macro". If you want to hide these lines in the edit pane you can use the collapse function (Text-Collapse) and use a search to identify blank lines and comments to hide them.
Sorry, I don’t think that is possible. Multi-Edit relies on line numbers (and column numbers) for many operations at a very low level. If you wanted a macro to count lines of code (not comments or blanks) that would be a possibility, but the line numbering itself would be very difficult.